CONFERENCE: Junior Investigator Participation in FASEB Conference on Biological Methylation to be held from July 21-26, 2001, at the Vermont Academy in Saxtons River, Vermont

这项资助为参加2001年7月21日至26日在佛特州萨克斯顿河举行的美国实验生物学协会联合会（FASEB）生物甲基化夏季研究会议的年轻研究人员提供支持。该会议是由FASEB主持的一系列两年一次的会议中的第五次会议，该会议始于1993年。这些会议的组织是为了响应会议的需要，重点是s -腺苷蛋氨酸（AdoMet），大多数生物甲基化反应的甲基供体，以及细胞中各种依赖AdoMet的转甲基化反应。2001年会议大约有一半的会议将集中讨论DNA的甲基化，因为DNA甲基化已被证明在基因表达、印迹和肿瘤发生的调节中发挥重要作用。会议将讨论的其他主题包括AdoMet与人类健康，涉及衰老和基因表达的各种蛋白质甲基化反应，以及化疗中重要的小分子甲基化反应。本次会议为对AdoMet甲基化和AdoMet代谢的各个方面感兴趣的科学家提供了一个独特的机会，这是其他任何会议都无法实现的。因此，这个会议传统上为富有成效的合作提供了起点。与会者的专业知识各不相同，从合成化学到分子生物学到生理学和医学。

This grant provides support for young investigators to attend the 2001 Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on Biological Methylation to be held on July 21-26, 2001, in Saxton River, VT. This conference is the fifth in a series of biennial conferences that began in 1993, under the auspices of the FASEB. These conferences were organized in response to the need for a conference with a focus on S-adenosylmethionine (AdoMet), the methyl donor for most biological methylation reactions, and the various AdoMet-dependent transmethylation reactions in cells. Approximately half of the 2001 meeting's sessions will be focused on the methylation of DNA, as DNA methylation has been shown to play important roles in the regulation of gene expression, imprinting and tumorigenesis. Other topics to be discussed at the meeting include the AdoMet and human health, various protein methylation reactions involved in aging and gene expression, and small molecule methylation reactions important in chemotherapy. This Conference provides a unique opportunity for scientists interested in various aspects of AdoMet methylation and AdoMet metabolism to interact, which is not achieved at any other conference. Consequently, this meeting has traditionally provided the starting point for productive collaborations. The expertise of attendees varies widely, ranging from synthetic chemistry to molecular biology to physiology and medicine.