RUI: Acquisition of a DNA Microarray Reader System

该合同支持获得DNA微阵列读取器和支持设备。该设备用于研究酵母和其他生物体基因组中所有基因的同时表达。这种全基因组表达的分析通常被称为功能基因组学；购买和操作功能基因组学所需设备的成本很高，通常超出了单个本科院校的能力。通过该奖项购买的设备，虽然位于一个机构，但将提供给来自全国各地的大学教师联盟，他们希望进行此类研究，但目前缺乏必要的设备。该设备将用于研究老化和dna结合化学物质对酵母基因表达的影响。此外，几位参与的教师将合作开发用于DNA微阵列数据集数学分析的新算法。这些用户是23名教师（来自美国和加拿大）的成员，他们组成了主动教学基因组联盟（GCAT）。在2000-2001学年，GCAT将协调一系列使用酵母DNA微阵列的功能基因组学实验，这些实验可以使用该奖项提供的设备进行测量。预期研究工作将对重要生物学领域的本科生培训（包括妇女和代表性不足的少数民族的培训）产生重大影响。

0099720CampbellThis award supports acquisition of a DNA microarray reader and supporting equipment. The equipment is required for studies of the simultaneous expression of all genes found in the genomes of yeast and other organisms. Such analysis of whole genome expression is usually referred to as functional genomics; the cost of purchasing and operating the equipment needed for functional genomics is high enough that it is generally beyond the means of single undergraduate institution. The equipment purchased through this award, though located at one institution, will be available to a consortium of college faculty from across the country who desire to pursue such research, but currently lack access to the necessary equipment. Research to be enabled by the equipment includes studies of the effect of aging and of DNA-binding chemicals on gene expression in yeast. In addition, several participating faculty will collaborate on an effort to develop new algorithms for mathematical analysis of DNA microarray datasets. The users are members of a group of 23 faculty (from the US and Canada) who have formed the Genome Consortium for Active Teaching (GCAT). During the 2000-2001 academic year, GCAT will coordinate a series of functional genomics experiments using yeast DNA microarrays that can be measured using the equipment provided through this award. The research efforts are expected to have a substantial impact on undergraduate training (including that of women and underrepresented minorities) in an area of biology of major importance.