Postdoctoral Research Fellowship in Biological Informatics for FY2001

这一行动为2001财政年度的NSF生物信息学博士后研究奖学金提供资金。 该奖学金支持生物学与信息、计算、数学和统计科学交叉领域的博士后水平的研究和培训。该研究金的目标是向一名青年科学家提供培训，为从事研究和教育相结合的生物信息学职业做准备。在各个职业层次上对生物信息学培训的需求日益增加，预计通过这些奖学金培训的研究员将在培训未来的劳动力方面发挥重要作用，该奖学金的研究和培训计划题为“神经活动如何指导视觉系统发育过程中发生的大脑结构的全系统修改？自发产生的“视网膜波”是早期视觉系统发育所必需的。 本研究使用理论和实验相结合的方法来确定（1）生理相关的神经输入如何在单个视网膜神经突触处引起适当的修改，以及（2）这些视网膜波驱动的修改如何导致驱动视网膜神经发育的系统范围内的竞争。

This action funds an NSF Postdoctoral Research Fellowship in Biological Informatics for FY2001. The fellowship supports research and training at the postdoctoral level at the intersection of biology and the informational, computational, mathematical, and statistical sciences. The goal of the fellowship is to provide training to a young scientist in preparation for a career in biological informatics in which research and education will be integrated. There is an increasing need for training in biological informatics at all occupational levels, and it is expected that Fellows trained through these fellowships will play important roles in training of the future workforce.The research and training plan for this fellowship is entitled "How does neural activity instruct the system-wide modifications in brain structure that occur during development of the visual system?" Spontaneously generated "retinal waves" are required for early visual system development. This research uses a combined theoretical and experimental approach to determine (1) how physiologically relevant neural input causes appropriate modifications at individual retinogeniculate synapses, and (2) how these retinal-wave-driven modifications result in system-wide competition that drives retinogeniculate development.