RUI - Acquisition of a Circular Dichroism Spectropolarimeter

收购圆二向色性光谱建议#0116741ABSTRACT已向斯佩尔曼学院的Lisa Hibbard博士授予赠款，以资助购买用于以下目的的圆二向色性(CD)光谱偏振仪：(1)PIS当前项目涉及使用光谱学技术研究眼睛晶状体蛋白a-晶体的结构和功能。(2)在生物化学实验课教学中，化学系将进行蛋白质结构测定实验。(3)它将用于光谱学实验室课程，该课程被提议作为学院化学系和物理系之间的桥梁课程。(4)克拉克-亚特兰大大学的研究人员与斯佩尔曼学院的教职员工合作，偶尔会使用这项技术。这项研究项目具有重要意义，因为关于a-晶体蛋白结构和伴侣功能之间的关系仍有许多需要了解。目前关于蛋白质的三级结构的信息很少，也没有人研究盐的存在和紫外线辐射对结构和功能的影响。此外，由于斯佩尔曼学院以培养优秀的非裔美国女科学家而自豪，这些项目将成为本科生进行生化研究的训练场。这种CD仪器还将用于斯佩尔曼化学和物理系的实验教学，以及亚特兰大地区的其他研究人员。来自代表性不足群体的学生将通过利用这一新工具的课程、实验室和研究项目接触到新技术。

ACQUISITION OF A CIRCULAR DICHROISM SPECTROPOLARIMETERNSF Proposal #0116741ABSTRACT A grant has been awarded to Dr. Lisa Hibbard at Spelman College to fund the acquisition of a circular dichroism (CD) spectropolarimeter to be used for the following purposes: (1) The PIs current project involves a study of the structure and function of the eye lens protein a-crystallin using spectroscopy techniques. (2) The Chemistry Department will perform protein structure determination experiments in the teaching biochemistry laboratory course. (3) It will be used in a spectroscopy laboratory-based course that is proposed as a bridging course between the departments of Chemistry and Physics at the College. (4) There will be occasional use by researchers at Clark-Atlanta University who are collaborators with faculty at Spelman College. The research project is of significance as there is still a great deal to be learned regarding the relationship between a-crystallin structure and chaperone function. Little information is currently available on the tertiary structure of the protein and no one has studied the effects of the presence of salt in conjunction with exposure to UV radiation on structure and function. In addition, as Spelman College prides itself on producing excellent African-American women scientists, these projects will serve as a training ground for undergraduate students to perform biochemical research. The CD instrument will also be available for use in teaching lab experiments in the Chemistry and Physics Departments at Spelman and by other researchers in the Atlanta area. Students from underrepresented groups will be exposed to new technologies through courses, laboratories, and research projects utilizing this new instrument.