Enhancement of the Organic Chemistry Laboratory Curriculum Using Temperature-Programmable, Computer-Controlled, and Network -Accessible Gas Chromatographs

化学（12）我们正在使用配备TCD检测器的温度可编程、计算机控制的气相色谱仪（gc）来完善、调整和整合一套全面的普通化学和有机化学序列实验。计算机控制的GCs提高了吞吐量，可以在校园内部网的任何地方访问所采集的数据和功能强大的数据分析软件。实验将我们创新的探究驱动的普通化学和化学平衡模式扩展到有机化学。通过对脂肪和油的分析，作为我们当前关于脂肪和营养的专题模块的一部分，学生们首先介绍了普通化学中的GC仪器。在有机序列中，几个关键的实验以一种调查性的、“假设”的方式由个别学生进行。例如，通过观察不同溶剂、烯烃和硼化试剂的作用，详细考察硼化反应的条件和机理细节。在另一个实验中，学生比较E1和E2消除2-溴丁烷得到顺式和反式2-丁烯。由于同分异构体可以通过气相色谱系统分离，相对产率导致对机理的深入了解。最后，气相色谱还被用于香水的跨学科课程，以及霍华德·休斯资助的“科学中的女孩和妇女”项目的社区外展活动，在这个项目中，六年级的女孩和她们的老师对汽油和其他常见材料进行“动手”气相色谱分析。我们正在由一名现场化学教育专家对该项目进行全面评估。我们将通过网站和nsf资助的ChemLinks联盟的链接，以及《化学教育杂志》上的文章，在全国范围内传播该项目的结果。

Chemistry (12)We are using temperature-programmable, computer-controlled gas chromatographs (GCs) equipped with TCD detectors to refine, adapt and incorporate a comprehensive set of experiments in the general and organic chemistry sequences. The enhanced throughput of the computer-controlled GCs provides access to the acquired data and powerful data analysis software anywhere on the campus intranet. The experiments extend our innovative inquiry-driven model for General Chemistry and Chemical Equilibrium to Organic Chemistry. Students are first introduced to GC instrumentation in General Chemistry through an analysis of fats and oils as part of our current topical module on fats and nutrition. In the Organic sequence, several key experiments are run in an investigative, "what if" fashion by individual students. For example, detailed examination of the conditions and mechanistic details of the hydroboration reaction by observing the effect of different solvents, alkenes, and hydroboration reagents are investigated by students. In another experiment, students compare E1 vs. E2 elimination of 2-bromobutane to give cis- and trans-2-butene. Since the isomers can be resolved by the GC system, the relative yields lead to insights about the mechanism. Finally, the GCs are also being used in an inter-disciplinary course on perfumes and in community outreach activities in a Howard Hughes-funded program for "Girls and Women in Science," where sixth grade girls and their teachers perform "hands-on" GC analyses of gasoline and other common materials. We are carrying a comprehensive assessment of the project by an on-site specialist in chemical education. We will disseminate the results of the project nationally through the web sites and links to the NSF-funded ChemLinks Coalition, as well as through articles in The Journal of Chemical Education once they become available.