Workshop on Genomics Approaches to Cis-Element/TF Interactions; Arlington, Virginia, January 16 -17, 2002

优点将于2002年1月16-17日在弗吉尼亚州阿灵顿举行的“顺式元件/转录因子相互作用的基因组学方法”研讨会的目的是将致力于计算方法的科学家与那些采用更传统的方法来识别顺式元件/转录因子相互作用的科学家聚集在一起。在过去的二十年里，研究人员通过研究单蛋白的DNA结合特性，即控制单基因表达模式的顺式元件，发现了调控序列。这导致了大约100个转录因子的结合位点的确定。这些研究极大地增加了我们对调控序列性质的认识，然而，对最近完成的基因组序列的分析表明，在大多数真核生物中存在超过1000个转录因子。因此，有可能存在尚未被发现的DNA结合蛋白的整个家族。这次研讨会的重点是将计算方法与全基因组采样技术相结合以识别功能调控序列方面取得的进展。目标是交流关于现有方法的信息，希望将建立跨学科合作，并播下新方法的种子。

0209634BenfeyThe purpose of the workshop on "Genomics approaches to cis-element/TF interactions", to be held in Arlington Virginia on January 16-17, 2002, is to bring together scientists working on computational approaches with those who have taken more traditional approaches to the identification of cis-element/transcription factor interactions. In the last twenty years, investigators have discovered regulatory sequences by studying the DNA binding characteristics of single proteins, or the cis elements that control the expression patterns of single genes. This has led to the identification of binding sites for around 100 transcription factors. These studies have greatly increased our knowledge of the nature of regulatory sequences, however, the analysis of recently completed genome sequences suggest that there are upwards of a thousand transcription factors in most eukaryotic organisms. Thus, it is probable that whole families of DNA-binding proteins exist that have not yet been discovered. This workshop will focus on advances being made in combining computational approaches with genome-wide sampling techniques to identify functional regulatory sequences. The goal is to exchange information on existing methodologies, with the hope that cross-disciplinary collaborations will be established and the seeds of new approaches will be sown.