GOALI: Characterization of Dense Colloidal Suspensions With Frequency-Domain Photon Migration (FDPM)

摘要提案号：cts -0213280首席研究员：Sevick-Muraca， Eva隶属机构：Texas Engineering Exp。在这个项目中，PI建议(i)开发和测试新的反算法，用于从实验多波长FDPM数据中评估单分散、二元和多分散悬浮液的粒径和粒径分布，（ii）评估由耗竭力、静电相互作用和具有生物学意义的配体受体系统功能化的胶体引起的FDPM测量散射特性的变化；(3)在局部结构因子第一性原理模型的背景下评价这些变化。GOALI项目的最终目标是开发一种低成本，简单的诊断工具，以表征密集悬浮液中胶体颗粒之间的相互作用。计划将该系统扩展到化学、制药和生物技术行业的中间和最终胶体产品的在线表征。

ABSTRACTProposal Number: CTS-0213280Principal Investigator: Sevick-Muraca, Eva MAffiliation: Texas Engineering Exp StaTitle: GOALI - Characterization of Dense Colloidal Suspensions with FDPMIn this project, the PI proposes to (i) develop and test new inverse algorithms for assessing particle size and size distribution in monodisperse, binary, and polydisperse suspensions from experimental multi-wavelength FDPM data, (ii) assess changes in FDPM measured scattering properties arising from depletion force, electrostatic interactions, and colloids functionalized with ligand receptor systems of biological significance; and (iii) evaluate those changes in the context of first principles models of partial structure factor. The final objective of the GOALI project is to develop a low cost, simple diagnostics tool in characterize the interaction between colloidal particles in dense suspensions. Extension of the system to on-line characterization of intermediate and final colloidal products is planned for chemical, pharmaceutical, and biotechnology industries.