RUI: Synthesis and Cyclization Chemistry of Functionalized Fluorinated Allenes

PI建议使用官能化的氟化联烯来开发新的氟化环构建方法。 他们将首先制备一些单氟和二氟联烯。 这些化合物的甲基化，烷基化和取代反应将进行研究，然后研究它们在环化反应中的用途，以制备氟化杂环和碳环。 有了这个奖项，有机和高分子化学计划是支持博士杰拉尔德B的研究。位于达特茅斯的马萨诸塞州大学的哈蒙德说。 哈蒙德博士和他的学生同事将研究一些被称为氟化联烯的有机氟分子的制备和反应化学。 许多药物和农用化学品都是含有机氟的分子，这个小组将开发新的合成灌浆到这些类型的分子。 在这项工作期间接受培训的学生将获得合成有机氟化学方面的经验，并获得制药和农业化学工业所需的技能。

The PI proposes to use functionalized, fluorinated allenes to develop new fluorinated ring construction methodologies. They will first prepare a number of mono and difluoroallenes. The metallation, alkylation and substitution reactions of these compounds will be investigated followed by a study of their use in cyclization reactions to prepare both fluorinated heterocycles and carbocycles. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Gerald B. Hammond of the University of Massachusetts at Dartmouth. Dr. Hammond and his student co-workers will study the preparation and reaction chemistry of a number of organofluorine molecules known as fluorinated allenes. Many pharmaceuticals and agrochemicals are organofluorine containing molecules and this group will be devloping new synthetic groutes to these types of molecules. Students trained during the course of this work will gain experience in synthetic organofluorine chemistry and be acquiring skills needed by the pharmaceutical and agrochemical industries.