Dendrimer Disassembly for Dendritic Amplification

麦格拉思教授和他的小组将致力于开发新的方法来控制树枝状材料的降解。 在许多树枝状聚合物中发现的苄基芳基醚亚基的酸不稳定性将被用作降解的触发剂。 具有可解聚主链的树枝状聚合物也将被制备和降解。 将监测已共价结合到树枝状聚合物中的降解片段的释放，以便可以理解该过程并在必要时进行修改。有了这个奖项，有机和大分子化学计划正在支持亚利桑那大学化学系的Dominic V.麦格拉思博士的研究。 麦格拉思博士和他的学生将致力于树枝状材料的可控降解。 树枝状材料的可控降解可能在药物的控制释放中具有潜在的应用，用于药物递送和作为用于微光刻的光致抗蚀剂的前体。 在这个跨学科的工作过程中培训的学生将获得制药，聚合物和特种化学品行业所需的技能。

Professor McGrath and his group will work on developing new methodology for the controlled degradation of dendritic materials. The acid lability of the benzyl aryl ether subunit found in many dendrimers will be used as a trigger for degradation. Dendrimers with depolymerizable backbones will also be prepared and degraded. Release of degradation fragments which have been covalently incorporated into the dendrimer will be monitored so that the process can be understood and modified as necessary.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Dominic V. McGrath of the Department of Chemistry at the University of Arizona. Dr. McGrath and his students will work on the controlled degradation of dendritic materials. Controlled degradation of dendritic materials could have potential applications in controlled release of pharmaceuticals for drug delivery and as precursors for photoresists for microlithography. The students trained during the course of this interdisciplinary work will gain skills needed by the pharmaceutical, polymer and speciality chemicals industries.