Development and Application of Dendrimer Disassembly

有了这个奖项，有机和高分子化学计划支持亚利桑那大学的多米尼克麦格拉思，他的研究将解决进一步的设计，开发和实施的控制树枝状聚合物降解技术被称为“树枝状聚合物拆卸”，最近在他的实验室开发。树枝状聚合物的分解依赖于一个单一的触发事件，在整个树枝状结构中引发多重裂解，导致单个树枝状聚合物亚基或更大的树枝状聚合物片段的释放。该过程的潜力在于树枝状聚合物作为活性物质的共价组装物的性质，并使用拆卸的化学过程将这些物质释放到系统中。进一步的优势包括系统的树枝状组分在影响溶解度、能量收集或绝缘能力方面的作用，以及使用分解的化学作用来逆转对系统的这些贡献。建议的工作提出了一个系统的，四部分的研究计划，以进一步发展树枝状大分子拆卸技术。首先是设计和实施新的合成策略，以更有效和更高产的方式制备分解的树枝状结构。第二，将制备基于根本不同的树枝状聚合物亚基的新的拆卸结构。第三，受控拆卸和亚基捕获研究将用于分析这些新系统的能力和反应性。第四，将启动新的有效实施拆卸结构作为其独特的反应性的应用。有了这个奖项，有机和高分子化学计划支持亚利桑那大学的多米尼克麦格拉思，他的研究将导致在纳米技术，树枝状聚合物拆卸一个全新的概念的进一步发展。作为本研究计划的一部分准备的材料将（a）用于传统的聚合物降解技术，（B）在纳米技术，生物医学和传感器技术方面具有潜在的增强能力。由于该研究计划是分子设计，合成和表征的连贯组合，并考虑到有机反应性，学生将在材料化学的更大领域获得广泛的经验。因此，这项研究非常适合研究生，博士后以及本科生的教育。事实上，麦格拉思教授小组的本科生在前一个项目期间已经取得了一些重大进展，这将在本项目期间通过对树枝状聚合物拆卸应用的研究得到加强。这些应用程序是跨学科的性质，跨学科的研究为本科生和研究生提供了一个独特的培训环境。

With this award, the Organic and Macromolecular Chemistry Program supports Dominic McGrath of the University of Arizona whose research will address the further design, development and implementation of the controlled dendrimer degradation technology known as 'dendrimer disassembly' that was recently developed in his laboratory. Dendrimer disassembly relies on a single triggering event to initiatemultiple cleavages throughout a dendritic structure that result in release of individual dendrimer subunits or larger dendrimer fragments. The potential of this process lies in the nature of dendrimers as covalent assemblages of active species, and using the chemistry of disassembly to release these species into a system. Further advantages include the role of dendritic components of a system in influencing solubility, energy harvesting, or insulating capabilities, and using the chemistry of disassembly to reverse those contributions to a system. The proposed work presents a systematic, four-part research plan to further develop dendrimer disassembly technology. First will be the design and implementation new synthetic strategies for preparing disassembling dendritic structures in a more efficient and higher yielding fashion. Second, new disassembling structures based on fundamentally different dendrimer subunits will be prepared. Third, controlled disassembly and subunit trapping studies will be used to assay the capability and reactivity of these new systems. And fourth, new effective implementations of disassembling structures as application of their unique reactivity will be initiated.With this award, the Organic and Macromolecular Chemistry Program supports Dominic McGrath of the University of Arizona whose research will result in the further development of an entirely new concept in nanotechnology, dendrimer disassembly. Materials prepared as part of this research plan will (a) be useful for traditional polymer degradation technologies, and (b) have potential enhanced capabilities in nanotechnology, biomedicine, and sensor technology. Since this research program is a coherent combination of molecular design, synthesis, and characterization, with important considerations of organic reactivity, students will obtain a broad array of experiences in the larger area of materials chemistry. Hence, this research is ideally suited to the education of graduate, postdoctoral, as well as undergraduate students. In fact, undergraduates in Professor McGrath's group have made several significant advances in the previous project period, which will be enhanced in this project period by the investigation of applications of dendrimer disassembly. These applications are interdisciplinary in nature, and interdisciplinary research provides a unique training environment for undergraduates and graduate students.