IL-1Beta Actions on CNS Neurons and Astrocytes

0078210 Friedman，W.白细胞介素-1B（IL-1B）是由脑中的神经胶质细胞产生的有效且多效性的细胞因子，其影响许多不同的细胞类型。 当IL-1B与神经胶质细胞上的受体相互作用时，它激活一种特异性的细胞内信号级联，诱导许多生长因子和细胞因子的产生。脑中的特定神经元群体，特别是海马神经元，也具有IL-1B的受体，然而神经元不产生响应于IL-1B的细胞因子和生长因子。 这种细胞因子激活的不同信号转导途径决定了不同细胞类型的功能反应。 因此，在这些研究中，我们将阐明不同的信号通路，介导的IL-1B在神经元相比，星形胶质细胞的行动。 另外，神经生长因子（nerve growth factor，NGF）是IL-1B诱导的胶质细胞生长因子之一。 神经胶质细胞中的一种NGF受体（p75）也被IL-1B诱导，这表明NGF对神经胶质的作用不同于其对神经元的良好特征性神经营养作用。这些研究将探讨神经生长因子对神经胶质细胞的信号通路和功能后果。生长因子和细胞因子影响许多不同的细胞群体，但诱导不同的反应，这是细胞类型特异性的。 阐明在神经元和神经胶质细胞中由多效性细胞因子如IL-1B激活的信号转导通路将允许洞察单个因子如何在不同的细胞类型中激活不同的信号传导事件和功能后果。

0078210Friedman, W.Interleukin-1B (IL-1B) is a potent and pleiotropic cytokine produced by glia in the brain which influences many different cell types. When IL-1B interacts with receptors on glia, it activates a specific intracellular signaling cascade inducing production of many growth factors and cytokines. Specific neuronal populations in the brain, in particular hippocampal neurons, also have receptors for IL-1B, however neurons do not produce cytokines and growth factors in response to IL-1B. The distinct signal transduction pathways activated by this cytokine determine the functional response of different cell types. In these studies, therefore, we will elucidate the different signaling pathways that mediate the actions of IL-1B in neurons compared to astrocytes. In addition, one of the growth factors which is induced by IL-1B in glia is nerve growth factor (NGF). One of the NGF receptors (p75) is also induced by IL-1B in glial cells, suggesting that NGF has effects on glia distinct from its well-characteristic neurotrophic effects on neurons. These studies will investigate the signaling pathways and functional consequences of NGF on glial cells.Growth factors and cytokines influence many different cell populations, but induce distinct responses which are cell type-specific. Elucidation of the signal transduction pathways activated in neurons and glia by a pleiotropic cytokine such as IL-1B will allow insight into how a single factor can activate different signaling events and functional consequences in distinct cell types.