MCAA: Role of Metal Ions in the T- to R-Allosteric Transition in the Insulin Hexamer

这个中期职业发展奖（MCAA）由无机，生物无机和有机化学计划支持教授韦伯W。Kadima在奥斯韦戈的纽约州立大学接受NMR技术和用于确定蛋白质结构的数据分析方法的培训。 前进博士将使用高场核磁共振技术研究金属离子的作用，如镉（II）和铁（III），胰岛素六聚体（R6）中T-至R-变构转变研究了金属离子对胰岛素与金属离子络合物的缔合和构象平衡的影响，并将结果应用于理解胰岛素在溶液中的行为及其调节和功能in vivo. PI将在附近的机构接受蛋白质结构测定方法的培训，这些方法将被带到纽约州立大学奥斯韦戈，以加强她涉及本科生的研究。

This Mid-Career Advancement Award (MCAA) by the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Professor Webe W. Kadima at the State University of New York at Oswego to pursue training in NMR techniques and data analysis methods used for the determination of protein structure. Dr. Kadima will use high field NMR technology to study the role of metal ions, such as Cd(II) and Fe(III), in the T- to R-allosteric transition in the insulin hexamer (R6) in solution.The effects of metal ions on the association and conformational equilibrium of insulin complexes with metal ions will be investigated and the results applied to understanding the behavior of insulin in solution and its regulation and function in vivo. The PI will receive training at nearby institutions in protein structure determination methods, which will be brought to SUNY Oswego to enhance her research involving undergraduates.