CAREER: Polynuclear Lanthanide-Oxo/Hydroxo Clusters - Design, Preparation, and Applications

这个无机，生物无机和有机化学计划的CAREER奖支持亚利桑那大学Zhiping Zheng教授的研究，以设计和合成一类新的多核镧系元素配合物，研究这些物质的性质，并探索其生物医学和先进的技术应用。主要目标是发展镧系元素配位化学的基本理解，在生理或更高的具有多种配体的pH条件，包括生物学相关的配体。 这些努力的目的是生产各种前所未有的镧系元素簇具有高度桥接氧和羟基基团，并阐明这些新的物质的形成的因素。 待探索的潜在应用包括用于生物医学成像的造影剂、用于液晶显示器的发光材料和磁光数据存储。 工作的广泛范围和模块化性质涉及跨学科的合作，并为各级学生的培训提供了多样化的机会。 根据拟议的研究，提出了教育活动，旨在建立一个明确的计划，材料化学集成到本科或研究生课程在亚利桑那大学。 最终目标是培养能够设计，合成，表征和测试新材料的科学家，以满足下一个世纪对先进性能材料的挑战性需求。 这一教育计划也将作为向公众传播化学科学的工具。

This CAREER award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Professor Zhiping Zheng at the University of Arizona to design and synthesize a novel class of polynuclear lanthanide complexes, to study the properties of these substances, and to explore their biomedical and advanced technological applications.The primary goal is to develop a fundamental understanding of lanthanide coordination chemistry under physiological or higher pH conditions with a variety of ligands, including those that are biologically relevant. These efforts are aimed at producing a variety of unprecedented lanthanide clusters featuring highly bridging oxo and hydroxo groups and at elucidating the factors governing the formation of these novel substances. The potential applications to be explored include contrast agents for biomedical imaging, luminescent materials for liquid crystal displays, and magnetooptical data storage. The broad scope and modular nature of the work involves cross-disciplinary collaborations and provides diverse opportunities for training of students at all levels. In line with the proposed research, educational activities are proposed aimed at establishing a well-defined program in Materials Chemistry integrated into the undergraduate or graduate curricula at the University of Arizona. The ultimate goal is to produce scientists who are capable of designing, synthesizing, characterizing, and testing new materials to meet the challenging demand for advanced-performance materials in the next century. This educational program will also serve as a vehicle to disseminate chemical science to the general public.