Development of a Matrix-Assisted Laser Desorption Source for a Fourier-Transform Microwave Spectrometer and the Rotational Spectroscopy of Large Biomolecules

在化学学部实验物理化学项目的支持下，Tubergen将使用傅里叶变换微波光谱仪研究溶剂分子对分子构象的影响。PI将开发用于傅里叶变换微波光谱仪的矩阵辅助激光解吸源。该源将被设计为蒸发生物分子而不分解。具体来说，生物分子，包括氨基酸和肽及其与水的配合物，将被研究。PI将邀请研究生和本科生参与他的研究。因此，他们将接受当代物理化学前沿领域的培训。PI还将开发适合物理化学教学实验室的新光谱实验。

In this project supported by the Experimental Physical Chemistry Program of the Chemistry Division, Tubergen will use a Fourier Transform Microwave Spectrometer to study the influence of solvent molecules on molecular conformation. The PI will develop a Matrix-Assisted Laser Desorption source for a Fourier transform microwave spectrometer. The source will be designed to vaporize biomolecules without decomposition. Specifically, biomolecules, including amino acids and peptides and their complexes with water, will be investigated.The PI will engage graduate and undergraduate students in his research. They will thereby receive training in forefront areas of contemporary physical chemistry. The PI will also develop new spectroscopic experiments suitable for a physical chemistry instructional laboratory.