Catalytic Asymmetric Acyl Halide-Aldehyde Cyclocondensations and Claisen Rearrangements

本研究的重点涉及两个方面。首先，将开发普遍适用的含有取代的烯酮亲核试剂的不对称酰基卤代醛环缩合变体。其次，将探讨Ir(I)催化的Claisen重排的非对映选择性和对映选择性变体。通过这一奖项，有机和高分子化学项目支持了匹兹堡大学化学系Scott G.Nelson博士的研究。纳尔逊教授将致力于开发有用的合成中间体的催化不对称合成方法学。这项研究对制药业有更广泛的影响，在制药业，制备对映体纯化合物至关重要。此外，该项目将为研究生的培训提供一个极好的舞台。

The foci of this research involve two areas. First, generally applicable asymmetric acyl halide-aldehyde cyclocondensation variants involving substituted ketene nucleophiles will be developed. Second, diastereoselective and enantioselective variants of Ir(I)-catalyzed Claisen rearrangements will be probed. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Scott G. Nelson in the Department of Chemistry at the University of Pittsburgh. Professor Nelson will focus his research efforts on developing methodology for the catalytic asymmetric synthesis of useful synthetic intermediates. The research has broader impact for the pharmaceutical industry where the preparation of enantiomerically pure compounds is crucial. Further, the project will provide an excellent arena for the training of graduate students.