Enantioselective Synthesis of b-amino acids

本研究的重点是在β -氨基酸的催化制备中使用非手性模板来影响表面选择性和增强反应性。该项目将利用手性继电器的概念开发三种互补的对映体控制方法：手性模板中的手性继电器，手性配体中的手性继电器和手性添加剂中的手性继电器。在实用价值方面，将制备α， β -二取代-氨基酸，并研究外选择性硝基和氧化腈环加成，Reformatsky反应，烯化反应和pinacol偶联。通过这个奖项，有机和大分子化学项目支持北达科他州立大学法戈化学系Mukund Sibi博士的研究。Sibi博士将专注于开发催化方法，以合成对映体纯形式的复杂β -氨基酸。β -氨基酸因其生物学特性而具有重要意义，该项目将在制药行业产生更广泛的影响。该项目还为本科生、研究生和研究生的培训提供了一个很好的场所。

The focus of this research involves the use of achiral templates to impact face selectivity and enhanced reactivity in the catalytic preparation of beta-amino acids. The project will develop three complementary methods for enantiocontrol using the concept of chiral relay: chiral relay in achiral templates, chiral relay in chiral ligands and chiral relay in achiral additives. In terms of practical value, alpha, beta-disubstituted beta-amino acids will be prepared and exo selective nitrone and nitrile oxide cycloadditions, Reformatsky reactions, allylations and pinacol couplings will be studied. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Mukund Sibi of the Department of Chemistry at North Dakota State University Fargo. Dr. Sibi will focus his work on developing catalytic methodology for the synthesis of complex beta-amino acids in enantiomerically pure form. Beta-amino acids are of significance due to their biological properties and the project will have broader impacts in the pharmaceutical industry. The project also provides an excellent venue for the training of undergraduate, graduate and postgraduate students.