New Cycloaromatization Reactions: Theory and Applications

本研究的重点是开发新型dna切割剂的实际应用，开发新的聚合物材料，以及它们的有机合成。本研究为有效控制和设计通过热、光化学和自由基-阴离子途径进行的新的环芳香化反应（Bergman环化）提供了理论基础。实验研究这些反应的机理，以更好地了解控制其效率的因素，并将这些发现应用于取代三醌和新型定义良好的高共轭碳“带”的合成。有了这个更新奖，有机和大分子化学项目支持了塔拉哈西佛罗里达州立大学化学和生物化学系的Igor Alabugin博士的研究和教育工作。阿拉布金教授将把他的研究重点放在开发切割DNA的新方法上。这项研究将有助于对使用反应性中间体的碳环闭合原理的基本理解。研究生、本科生和博士后水平的化学学生将在阿拉布金教授的实验室接受培训。

The focus of this research is in the development of practical applications for novel DNA-cleaving agents, the development of new polymeric materials, and for their organic synthesis. This research provides a theoretical basis for the efficient control of known and design of new cycloaromatization reactions (Bergman cyclizations) proceeding through thermal, photochemical and radical-anionic pathways. The mechanisms of these reactions will be studied experimentally to obtain a better understanding of factors controlling their efficiency, and the findings will be applied to synthesis of substituted triquinanes and new types of well-defined highly-conjugated carbon "ribbons".With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Igor Alabugin of the Department of Chemistry and Biochemistry at the Florida State University, Tallahassee. Professor Alabugin will focus his research on the development of new ways to cleave DNA. This research will contribute to the fundamental understanding of the principles governing the closure of carbon rings using reactive intermediates. Chemistry students at the graduate, undergraduate and post-doctoral level will be trained in Professor Alabugin's laboratory.