Origin and Evolution of Mammalian Dosage Compensation

主要的好处是为澳大利亚的知识基础做出贡献，并提高澳大利亚功能性比较基因组学的形象，其研究重点是“建设和改造澳大利亚产业的前沿技术”，优先目标是“突破性科学和前沿技术”。这个项目解决了哺乳动物X染色体失活进化的基本问题，作为表观遗传变化的重要模型，以及性染色体，这已经吸引了近世纪的一些最伟大的遗传学家。因此，我的研究结果将吸引广泛的国际兴趣，并对澳大利亚的科学形象产生积极的影响，并进一步突出澳大利亚哺乳动物的重要性。

The primary benefits are contribution to Australia's knowledge base and raising the profile of functional comparative genomics in Australia, with the research priority of 'Frontier Technologies for Building and Transforming Australian Industries' and priority goals in 'Breakthrough Science and Frontier Technologies'. This project addresses fundamental questions about the evolution of mammalian X-chromosome inactivation, of importance as a model for epigenetic change, and sex chromosomes, which has engaged some of the greatest genetic minds over nearly a century. Therefore my results will attract wide international interest and impact positively on Australia's scientific profile, and further highlight the importance of Australian mammals.