Evolution and function of mammalian sex chromosomes

哺乳动物性染色体的进化和功能

• 批准号: DP210103512
• 负责人: Prof Frank Gruetzner
• 金额: $ 57.16万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-06-02 至 2024-05-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103512
• 关键词: Evolution; function; mammalian; sex; chromosomes

Research on iconic Australian mammals has profoundly reshaped our understanding of reproductive biology and sex chromosome evolution. In this project we combine unique expertise, international collaboration and novel genetic information about Australia's unique egg-laying mammals (echidna and platypus) to investigate major aspects of reproduction. This work will address fundamental aspects of sex chromosome biology and advance our understanding of mammalian reproduction. The knowledge gained will have application in captive breeding and conservation of these extraordinary Australian mammals. The project also provides opportunity to train research students in cutting edge molecular biology and informatics.

对标志性的澳大利亚哺乳动物的研究深刻地重塑了我们对生殖生物学和性染色体进化的理解。在这个项目中，我们结合联合收割机独特的专业知识，国际合作和澳大利亚独特的产卵哺乳动物（针鼹和鸭嘴兽）的新的遗传信息，调查繁殖的主要方面。这项工作将解决性染色体生物学的基本方面，并推进我们对哺乳动物生殖的理解。所获得的知识将应用于圈养繁殖和保护这些非凡的澳大利亚哺乳动物。该项目还提供了机会，培养研究生在尖端分子生物学和信息学。