SBIR Phase I: DNA-Based Chemosensors for Direct Detection of Volatile Compounds

这个小型企业创新研究(SBIR)第一阶段项目将开发一种新的便携式传感器阵列设备，直接基于生物学原理，用于快速检测、识别和量化环境中的挥发性化合物。实验室和现场测试表明，该平台具有足够的灵敏度，可以探测和识别埋在地下的TNT填充地雷的蒸汽特征。这个SBIR第一阶段项目的重点是在设备中引入一种新的传感技术，利用最先进的微阵列设备，使用染料标记的DNA直接检测挥发性化学物质。该产品的商业应用将作为一种轻型、低成本、手持的挥发性化学检测系统，用于快速检测爆炸物、化学战剂和其他危险材料的安全筛查。其他潜在用途包括医疗诊断和环境监测。

This Small Business Innovation Research (SBIR) Phase I project will develop a novel portable sensor array device, based directly on biological principles, for rapidly detecting, identifying, and quantifying volatile compounds in the environment. Lab and field tests show that this platform is sensitive enough to detect and discriminate the vapor signature of buried TNT-filled landmines. This SBIR Phase I project focuses on incorporating into the device a novel sensing technology that uses dye-labeled DNA to directly detect volatile chemicals with the use of state-of-the-art microarray equipment.The commercial application of the product will be as a lightweight, low-cost, hand-held volatile chemical detection system for use in security screening for the rapid detection of explosives, chemical warfare agents, and other hazardous materials. Other potential uses include medical diagnostics and environmental monitoring.