MRI/RUI-Acquisition of A High Field NMR for Chemistry Research

汉密尔顿学院化学系将获得一台400兆赫核磁共振光谱仪，该奖项来自主要研究仪器（MRI）项目。该设备将使研究人员能够开展以下研究：a)海洋藻类中溴allene形成的立体化学；B)紫苑和以其为寄主植物的蝴蝶的化学生态学研究；C)海绵中生物活性物质的分离和结构；D)模拟甲胎蛋白最小活性序列的合成肽的构象研究；E)自由基化学合成方法和机理研究的发展；f)探究一氧化氮氧化神经递质的本质。核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将对海洋研究、合成有机化学和生物化学产生影响。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Hamilton College will acquire a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out research on a) the stereochemistry of bromoallene formation in marine algae; b) investigation of the chemical ecology of asters and the butterflies that use them as host plants; c) isolation and structure of bioactive substances from a sponge; d) a conformational study of synthetic peptides that mimic the minimal active sequence of alpha fetoprotein; e) the development of synthetic methodology and mechanistic studies in free radical chemistry; and f) probing the nature of the nitric oxide oxidation of neurotransmitters. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in marine studies, synthetic organic chemistry and biochemistry.