MRI/RUI: Acquisition of an Isothermal Titration Calorimeter

在主要研究仪器(MRI)计划的支持下，里德学院化学系将获得一台等温滴定量热仪。该设备将加强若干领域的研究，包括a)测定依赖金属离子的调节蛋白对同源和非同源金属离子的亲和力以及结合的化学计量学；b)酶机制研究；c)研究多肽抗生素杆菌肽的生物活性类似物。量热法在现代分析化学中是一种非常有用的工具。量热分析用于测量分子相互作用和反应过程中发生的热能(热)交换。因此，它可以提供一种非常可靠和灵敏的方法来确定材料的热力学性质，如液体和固体样品的热容变化。里德学院是一所本科院校，这些工具的可获得性将对本科生的研究产生强烈影响。

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Reed College will acquire an isothermal titration calorimeter. This equipment will enhance research in a number of areas including a) the determination of the affinity of metal ion-dependent regulatory proteins for cognate and non-cognate metal ions and the stoichiometry of combination; b) studies on enzyme mechanisms; and c) investigations into biologically active analogs of the polypeptide antibiotic bacitracin. Calorimetry is an extremely useful tool in modern analytical chemistry. Calorimetric analysis is used to measure the thermal energy (heat) exchange that occurs during molecular interactions and reactions. Thus it can provide a very reliable and sensitive method for determining the thermodynamic properties of materials such as changes in heat capacity of liquid and solid samples. Reed College is an undergraduate institution, and the availability of these instruments will have a strong impact on undergraduate research.