ADAPtive T cell migration into the stressed brain (B12)

ADAP-SKAP55蛋白形成一个分子复合体，调节T细胞的黏附和迁移。我们在第二个资助期的发现表明，这两种蛋白质在调节膜支架和肌动蛋白细丝组织方面发挥了作用。我们现在计划通过结构、生化和分子生物学技术来描述它们在肌动蛋白介导的T细胞迁移中的作用。我们将利用我们的机械洞察力，在小鼠身上探索ADAP-SKAP55及其相互作用伙伴在应激诱导的T细胞外溢到脑膜间隙中的作用，并阐明它们与T细胞支持的认知功能和应对创伤应激的相关性。

The ADAP-SKAP55 proteins form a molecular complex that regulates adhesion and migration of T cells. Our findings from the 2nd funding period suggest a role of the two proteins in modulating membrane scaffolding and actin filament organization. We now plan to delineate their contribution to actin-mediated migration of T cells by structural, biochemical and molecular biology techniques. We will exploit our mechanistic insights to probe in mice the role of ADAP-SKAP55 as well as their interaction partners in stress-induced T cell extravasation into the brain meningeal space and clarify their relevance for T cell-supported cognitive functioning and coping with traumatic stress.