Supramolecular Fixation of Nitrogen Dioxide

在化学系有机动力学项目的支持下，德克萨斯大学阿灵顿分校的Dmitry Rudkevich教授提出合成和研究封装化学笼的活性，这些化学笼捕获氮氧化物物种，并可以通过化学设计来催化具有环境和生物意义的反应。Rudkevich教授提出将一系列杯芳烃-NO+化合物作为新型亚硝化剂用于有机合成。包封的NO+的降低的反应性将用于实现选择性亚硝化。他还将研究与一系列醇，硫醇和酰胺的立体选择性和区域选择性反应中封装亚硝基化试剂的反应性和速率。将采用系统方法获得关于新试剂和改良试剂的反应性和选择性的信息。这些原则将有助于特定催化剂的合理设计，并将在工业和药物合成中得到应用。有机和高分子化学计划支持德克萨斯大学阿灵顿分校的德米特里·鲁德克维奇教授，他将展示NOx的有用应用，NOx是一种重要的空气污染物。如果既定目标得以实现，Rudkevich教授将扩大目前在杯芳烃和纳米管领域的知识。将使用的实验和理论工具将给学生在现代合成化学的曝光和实践经验。

With the support of the Organic Dynamics Program in the Chemistry Division, Professor Dmitry Rudkevich of the University of Texas- Arlington proposes to synthesize and investigate the activity of encapsulating chemical cages that trap nitrogen oxide species and can be manipulated through chemical design to catalyze reactions of environmental and biological significance. Professor Rudkevich proposes to use a series of calixarene-NO+ compounds as novel nitrosating agents for organic synthesis. The decreased reactivity of encapsulated NO+ will be used to achieve selective nitrosation. He will also examine the reactivity and rates of encapsulating nitrosating reagents in stereoselective and regioselective reactions with a series of alcohols, thiols, and amides. A systemic approach will be used to gain information on the reactivity and selectivity of new and modified reagents. It is anticipated that these principles will help in the rational design of specific catalyst with future applications to industrial and pharmaceutical syntheses. The Organic and Macromolecular Chemistry Program supports Professors Dmitry Rudkevich of the University of Texas- Arlington who will demonstrate useful applications of NOx which is known to be a significant air pollutant. If the stated goals are achieved, Professor Rudkevich will expand the knowledge currently available in the field of calixarenes and nanotubes. The experimental and theoretical tools that will be used will give students exposure and hands-on experience in modern synthetic chemistry.