NER: An AFM-based Technique for Nanoscale Flow Mapping

建议编号：CTS-0404167研究人员：THEODORIAN Borca-TASCIUCINSTUTION：伦斯勒理工学院INST.NER：一种基于AFM的纳米流图技术该建议是对纳米科学与工程倡议，NSF 03-043，NER类的响应。了解纳米结构和液-固界面内和周围流动的动力学和结构对于发展基于流体的生物和化学传感器是至关重要的。目前已有的流场表征方法，如激光多普勒测速(LDV)和粒子图像测速(PIV)等都依赖于光学传感，且分辨率受光波长的限制。根据这项资助，将开发一种基于磁力显微镜(MFM)检测铁磁或顺磁纳米颗粒播撒流动的新实验技术。然后，该技术将被用于测量电渗透微通道流中的流场以及流动中DNA分子附近的流场。这些实验将为开展与生物流体和生物传感应用相关的流动研究奠定基础，例如含有DNA分子的流动。这个项目的挑战将由一个在实验测量和理论建模和计算方面拥有专业知识的团队来应对。拟议的研究如果成功，将有助于理解纳米尺度上流体流动的关键方面，并将为设计更好的用于化学和生物传感和纳米制造的微流体和纳米流体系统铺平道路。此外，通过促进对DNA和其他生物分子和单个细胞附近流动的研究，这项技术将为理解生物系统中的生理过程开辟新的视野。这将对生物技术产生巨大影响。拟议的研究活动与一项全面的教育和推广方案相结合。结果将通过一个新的触觉设备界面和在线可访问的实验和演示纳米级流体流动现象由本科生开发。

PROPOSAL NO.: CTS-0404167PRINCIPAL INVESTIGATOR: THEODORIAN BORCA-TASCIUCINSTITUTION: RENSSELAER POLYTECHNIC INST.NER: AN AFM-BASED TECHNIQUE FOR NANOSCALE FLOW MAPPING This proposal was received in response to Nanoscale Science and Engineering initiative, NSF 03-043, category NER. Understanding the dynamics and the structure of flows in and around nanostructures and liquid-solid interfaces is critical for the advancement of future generations of fluidic based biological and chemical sensors. Currently available flow field characterization methods such as Laser Doppler Velocimetry (LDV) and Particle Image Velocimetry (PIV) rely on optical sensing and are limited in resolution by the wavelength of light. A novel experimental technique based on Magnetic Force Microscopy (MFM) detection of ferromagnetic or paramagnetic nano-particles seeding the flow will be developed under this grant. The technique will then be utilized for measurements of the flow field in electroosmotic microchannel flows and in the vicinity of a DNA molecule in the flow. These experiments will set the stage to conduct studies of flows relevant to bio-fluidic and bio-sensing applications such as flows containing DNA molecules. The challenges of this project will be met by a team with expertise in both experimental measurements and theoretical modeling and computation. The proposed research, if successful, will lead to an understanding of key aspects of fluid flow at the nanoscale, and will pave the way for designing better microfluidic and nanofluidic systems for chemical and biological sensing and nanomanufacturing. Moreover, by facilitating the study of flows in the vicinity of DNA and other bio-molecules and individual cells this technique will open new horizons for understanding physiological processes in biological systems. This will have a tremendous impact on biotechnology. The proposed research activity is integrated with a comprehensive educational and outreach program. The results will be made available through a novel haptic device interface and on-line accessible experiments and demonstrations of nanoscale fluid flow phenomena to be developed by undergraduate students.