Chemistry of High-Energy Content Reagents

有了这个基于更新奖的成就，有机和高分子化学计划继续支持教授加里B的工作。舒斯特说，他是佐治亚州亚特兰大市格鲁吉亚理工学院化学和生物化学系的教授。 该研究将继续PI对影响DNA中电荷传输的因素的调查。 一般的方法是在DNA链上放置电子供体，光生自由基阳离子，使电荷沿着链迁移，并用更强的电子供体捕获电荷。 将评估影响该过程速率的各种因素。 特别是，电荷迁移中的DNA抗衡离子的作用，质子转移的过程中的影响，以及水在电荷传输中的作用将使用这种技术进行探讨。 为了评估这些实验与可溶性DNA氧化损伤的相关性，将研究DNA凝聚物中的电荷迁移，这些研究预计将对生物科学产生广泛的影响。 特别是，它们将有助于我们了解DNA损伤和修复机制的因素及其与基因突变的潜在关系。此外，该研究将为学生提供广泛的跨学科培训，范围从核酸化学到纳秒光谱学。

With this accomplishment based renewal award, the Organic and Macromolecular Chemistry Program continues its support for the work of Professor Gary B. Schuster of the Department of Chemistry and Biochemistry at the Georgia Institute of Technology in Atlanta, GA. The research will continue the PI's investigations of the factors affecting charge transport in DNA. The general approach will be to place an electron donor on a DNA chain, photogenerate a radical cation, migrate the charge along the chain, and trap the charge with a stronger electron donor. Various factors influencing the rate of this process will be evaluated. In particular, the role of the DNA counterions in charge migration, the effect of proton transfers on the process, and the role of water in charge transport will be probed using this technique. In order to assess the relevance of these experiments with soluble DNA to oxidative damage in genomic DNA, charge migration in DNA condensates will be investigated.These studies are expected to have broad impact upon the biological sciences. In particular, they will contribute to our knowledge of factors responsible for DNA damage and repair mechanisms and their potential relationship to genetic mutations. In addition the research will provide broad interdisciplinary training for students in areas ranging from nucleic acid chemistry to nanosecond spectroscopy.