Mechanisms controlling cell adhesion and motility in zebrafish stem cell proliferation zones (A01)

发育中的干细胞生态位为细胞离开严密控制的黏附环境入侵邻近组织提供了一种范例。在A1中，将结合遗传学方法、活体成像和单细胞转录学来研究丘脑背侧神经增殖区的细胞行为，以识别和研究黏附和迁移的分子控制。归根结底，这个项目的目的是了解干细胞通过离开它们的利基成为迁徙的祖细胞所经历的转变。

Developmental stem cell niches provide a paradigm for cells leaving a tightly controlled adhesion environment to invade adjacent tissues. In A1 cell behavior in the dorsal thalamic neural proliferation zone will be studied by combining genetic approaches, live-imaging and single cell transcriptomics for identifying and studying the molecular control of adhesion and migration. Ultimately this project aims for understanding the transitions that stem cells undergo by leaving their niche to become migrating progenitors.