Acquisition of a High-Field Multi-Nuclear FT-NMR Instrument

在Michael P. Groziak博士的指导下，加州州立大学海沃德分校获得了一笔资助，用于支持一种紧凑、高场（400 MHz）、多核傅里叶变换核磁共振（FT-NMR）仪器系统。一个由四个活跃的研究教育工作者组成的核心小组将管理这个核磁共振仪器系统，他们将根据实际操作这些设备来进行自己的研究，并帮助校园内外的其他研究人员进行核磁共振相关的研究。购买的仪器是市场上最紧凑的，它配备了计算机工作站，最先进的软件和各种探针，用于记录元素周期表中许多不同原子核的信号。核心用户已经建立了他们的研究实验室，他们已经吸引了学生加入他们的小组，并且他们已经获得了传统上由NSF支持的领域的外部研究资金。他们的研究重点是生物有机和生物物理化学领域，他们准备在这些领域推进科学知识和理解。具体来说，他们将研究病毒膜蛋白和核酸，新的硼杂环和拴链核苷酸，酶抑制剂，小分子与人工膜系统的相互作用，以及细胞色素P450氧化有机污染物的代谢物。该仪器将纳入新闻部的教学课程，以便培训年轻的研究人员。所有这些以研究为中心的努力的结果将在会议报告和科学出版物中广泛传播，并将在新闻部的网站上突出显示。由于核心用户群体以前使用这类仪器的丰富经验，他们完全有资格维护它，并充分利用它来支持他们自己和其他人的研究工作。加州州立大学海沃德分校是科罗拉多州立大学系统中最后几个获得这种现代核磁共振仪器的大学之一。它是一所本科研究机构，在授予少数民族学生学士学位方面排名全国第39位。这种仪器在校园的存在将激发大量少数民族和女学生对从事化学科学和相关领域的研究活动和学位的更大兴趣。这一期望得到了该系毕业生业绩记录的支持，它正在参与几个非常成功的少数民族研究项目，以及整个大学的学生组成。该仪器将对许多以研究训练为重点的实验室课程产生直接和有意的影响，从而为学生提供更多的鼓励，使他们作为高年级学生参与核磁共振相关的研究活动。最后，它将对整个社会产生重大影响。特别是，在加州大学海沃德分校附近的社区学院，当他们运行光谱、举办讲习班培训课程、举办研讨会并提供使用这一现代研究仪器的机会时，将得到核心用户的良好服务。

A grant has been awarded to California State University-Hayward under the direction of Dr. Michael P. Groziak for support of a compact, high-field (400 MHz), multi-nuclear Fourier Transform Nuclear Magnetic Resonance (FT-NMR) instrument system. A core group of four active researcher-educators will manage this NMR instrument system, conducting their own research dependent upon hands-on access to just such equipment and helping other researchers both on and off campus with NMR-related research. The instrument being acquired is the most compact on the market, and it is equipped with a computer workstation, state-of-the art software, and various probes for recording signals from many different nuclei in the periodic table.The core users have set up their research laboratories, they have attracted students to their groups, and they have already obtained external funding for research in areas traditionally supported by the NSF. The focus of their investigations is in the fields of bio-organic and biophysical chemistries, where they are poised to advance scientific knowledge and understanding. Specifically, they will be studying viral membrane proteins and nucleic acids, new boron heterocycles and tethered nucleotides, enzyme inhibitors, the interaction of small molecules with artificial membrane systems, and metabolites of cytochrome P450 oxidation of organic contaminants. The instrument will be integrated into the Department's teaching curriculum for the purpose of training young researchers. The results of all of these research-centered efforts will be broadly disseminated in meeting presentations and scientific publications, and they will be highlighted on the Department's Web site. Because of their prior extensive experience with this type of instrument, the core users group is well qualified to maintain it and to use it to its full capacity to support their research efforts and those of others.California State University-Hayward is one of the last few remaining in the CSU system to obtain this type of modern NMR instrument. It is an Undergraduate Research Institution ranking 39th in the nation for granting baccalaureate degrees to minority students. The presence of this instrument on campus will stimulate an enhanced interest among a large number of minority and female students to pursue research activities and degrees in the chemical sciences and related fields. This expectation is supported by the Department's graduating student track record, its ongoing participation in several highly successful minority research programs, and by the student composition of the University as a whole. The instrument will have an immediate and deliberate impact upon many of the Department's research training-focused laboratory courses, thus providing even more encouragement for students to become involved in NMR-related research activities as upperclassmen. Finally, it will have a significant impact upon the larger society as a whole. In particular, the community colleges in the immediate vicinity of CSU-Hayward will be well served by the core users when they run spectra, hold workshop training sessions, present seminars, and provide access to this modern research instrument.