STTR PHASE I: Nano-Porous Glass-Coated Amorphous Metal Wires for Integrated Solid-Phase Microextraction Devices

这个小型企业技术转移（STTR）第一阶段项目将开发玻璃涂层非晶金属（GCAM）纤维，其中玻璃涂层在纳米级上是多孔的。热处理将用于在涂层中产生相分离。玻璃的可溶成分将被浸出，留下不溶相的多孔骨架。多孔GCAM纤维将被用作固相微萃取（SPME）设备，用于从液体基质中取样分析物，如药物和生物分子，从气体基质中取样挥发性有机化合物。GCAM纤维的独特之处在于，金属芯可以通过磁感应加热，从而可以快速加热多孔涂层并快速解吸分析物。该项目的商业应用将是工业和环境监测，以及各种安全应用。拟议的技术将促进现场收集和转移到实验室设备（如气相色谱仪）后监测设备快速、现场释放关键样品进行分析。相比之下，目前的SPME设备需要外部加热来解吸分析物。

This Small Business Technology Transfer (STTR) Phase I project will develop glass-coated amorphous metal (GCAM) fibers in which the glass coating is porous on the nano-scale level. Thermal treatments would be used to produce phase separation in the coating. The soluble component of the glass would be leached, leaving behind a porous skeleton of the non-soluble phase. The porous GCAM fibers will be employed as solid-phase micro-extraction (SPME) devices for the sampling of analytes such as pharmaceuticals and biomolecules from liquid matrices and volatile organic compounds from gaseous matrices. The GCAM fiber is unique in that the metal core can be heated via magnetic induction, allowing for rapid heating of the porous coating and rapid analyte desorption. The commercial application of this project will be in industrial and environmental monitoring, and in various security applications. The proposed technology will facilitate rapid, in-situ release of key samples for analysis from monitoring devices following field collection and transfer to laboratory based equipment such as gas chromatographs. In contrast, current SPME devices require external heating to desorb the analyte.