RUI: Mechanism and Kinetics of Oxidation of Guanosine Derivatives by Pt(IV) Complexes

米德尔伯里学院化学系的Sunhee Choi教授受到无机、生物无机和有机金属化学项目的支持，她的生物无机化学研究是关于鸟苷衍生物被Pt（IV）配合物氧化的机制和动力学，这些配合物与生物学上重要的抗癌剂有关。各种铂（IV）配合物将被合成和表征。紫外可见光谱，1H和31P NMR， HPLC和质谱将用于确定Pt（IV）配合物的还原电位如何影响氧化还原动力学。这些研究结果将增强对过渡金属/DNA化学的基本认识。本研究将从生物无机化学的角度研究Pt（IV）配合物氧化鸟苷衍生物的机理和动力学。铂配合物是生物学上重要的抗癌药物。这些生物无机化学研究将提供对Pt（IV）物种氧化DNA的分子水平的理解，并增强对过渡金属/DNA化学的基本理解。本科学生将接受多方面的培训，包括无机合成和表征，以及利用过渡金属配合物探测核酸毒理学和药理学。

Professor Sunhee Choi of the Chemistry Department at Middlebury College is supported by the Inorganic, Bioinorganic and Organometallic Chemistry program for her bioinorganic chemistry studies on the mechanism and kinetics of the oxidation of guanosine derivatives by Pt(IV) complexes, complexes related to biologically important anticancer agents. Various Pt(IV) complexes will be synthesized and characterized. UV-visible spectroscopy, 1H and 31P NMR, HPLC and mass spectroscopy will be used to determine how the reduction potentials of Pt(IV) complexes affect the redox kinetics. Results of these studies will enhance the basic understanding of transition metal/DNA chemistry. This research will focus on the bioinorganic chemistry studies on the mechanism and kinetics of the oxidation of guanosine derivatives by Pt(IV) complexes. Platinum coordination complexes are biologically important anticancer agents. These bioinorganic chemistry studies will provide molecular level understanding of the oxidation of DNA by Pt(IV) species and enhance the basic understanding of transition metal/DNA chemistry. Undergraduate students will receive multifaceted training in inorganic synthesis and characterization and the use of transition metal complexes in probing nucleic acid toxicology, and pharmacology.