Star Porphyrazines

西北大学化学系Brian Hoffman博士由化学部无机化学、生物无机化学和有机金属化学项目支持，致力于星形卟啉(PZS)的研究。将对三个主要领域进行调查。首先，含有核心金属离子和外围金属离子的氨基功能化PZ将被用来定义异金属自旋耦合的系统学，二硫代官能化PZ将被用作PZ组装和金属连接PZ带的基础，这些PZ带包括氧化还原可切换的传导和/或自旋耦合。其次，PZS将被用来研究分子与金属表面的接近/取向如何影响界面电荷注入的基本问题，可能应用于分子电子传输结、发光二极管和光伏系统。吸附在银纳米粒子上的卟嗪分子的光学跃迁与粒子的局域表面等离子体共振强耦合。这一现象将被探索并应用于化学和生物光学纳米传感器。该奖项支持的工作将对各种科学技术应用产生重大影响。这类被称为星形卟嗪的化合物将在肿瘤的生物成像以及双光电/电化学金属离子传感器等应用中作为造影剂非常有用。PZS还有望生产出浸笔式纳米光刻“墨水”，这种墨水可以用来在表面形成具有受控电学性质的图案。学生和博士后将不仅在这些化合物的合成和物理表征方面获得基本的和不同的技能，而且在探索所产生的产品在纳米技术、生物成像和传感器方面的潜在应用方面也将获得不同的技能。

Dr. Brian Hoffman, Department of Chemistry, Northwestern University, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program of the Chemistry Division for work on star porphyrazines (pzs). Three general areas will be investigated. First, amino-functionalized pzs containing a core metal ion and metal-ions bound at the periphery will be used to define the systematics of heterometallic spin coupling and dithiolato-functionalized pzs will be used as the basis of pz assemblies and metal-linked pz ribbons that incorporate redox-switchable conduction and/or spin coupling. Secondly, pzs will be used to study fundamental questions about how molecular proximity/orientation to a metal surface influences interfacial charge injection, with possible applications as molecular electronic transport junctions, light emitting diodes and photovoltaic systems. Thirdly, the molecular optical transitions of porphyrazines adsorbed on Ag nanoparticles strongly couple to the particle localized surface plasmon resonances. This phenomenon will be explored and applied as chemical and biological optical nanosensors. The work supported by this award will have significant impact on a variety of scientific and technological applications. The class of compounds known as star porphyrazines will be highly useful as contrast agents in bio-imaging of tumors, and in such applications as dual opto/electrochemical metal-ion sensors. Pzs also hold promise of yielding dip-pen nanolithography "inks" that can be used to form patterns with controlled electrical properties on surfaces. Students and post-doctoral associates will gain fundamental and diverse skills not only in syntheses and physical characterization of these compounds, but also in exploring the potential application of the resulting products in nanotechnology, bio-imaging, and sensors.