Design, Synthesis, and Photochemistry of New Ru(II) Complexes as Potential Photo-Cisplatin Analogs

Claudia Turro教授是俄亥俄州立大学化学系的一名教员，她与来自德州农工大学的Kim Dunbar教授共同担任项目负责人。她得到了无机、生物无机和有机金属化学项目的支持，设计出可以光激活并与DNA结合的金属复合物。新的钌配合物将被开发，以提供一种替代光动力治疗剂，产生单线态氧作为反应物质。用低能光活化金属试剂，将活化的配合物定位在辐照区域。顺式铂作为抗肿瘤药物的作用有严重的局限性，因此需要寻找替代金属配合物作为DNA结合剂。选择性光活化钌复合物的可能性，将结合到DNA驱动这个研究项目。广泛的配位化学、生物化学和光化学训练为学生提供了多种优势，同时发展了重要的基本光物理原理。

Professor Claudia Turro, a faculty member in the Department of Chemistry at Ohio State University, with Professor Kim Dunbar from Texas A& M University as the co-PI, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program to design metal complexes that can be photoactivated and bind to DNA. New ruthenium complexes will be developed to provide an alternative to photodynamic therapy agents that generate singlet oxygen as the reactive species. Activation of the metal reagent via photoaquation with low energy light will localize the activated complex in the irradiated area. The role that cis-platin plays as an antitumor drug includes severe limitations that justify seeking alternative metal complexes as DNA binders. The possibility of selective photoactivation of ruthenium complexes that will bind to DNA drives this research project. Broad based training in coordination chemistry, biochemistry and photochemistry offer multiple advantages to students while developing important fundamental photophysical principles.