Investigation of bone defects and microcirculation with volume computed tomography and dy-namic contrast-enhanced magnetic resonance imaging ((13) B08)

临床研究：继续第二阶段开始的队列研究，纳入更多阴燃多发性骨髓瘤患者，以便在发生明显的骨破坏之前检测骨髓损害。对新发现的骨髓病变进行高分辨率和功能磁共振成像以及正电子发射断层扫描，并在影像引导下对非溶骨性病变进行活检。临床前研究：使用超高频小型动物MRI和微型CT，以及使用标准和BCMA示踪剂(SPB13)的PET，使用大鼠和小鼠模型在体内分析灌注、扩散和细微骨结构(SPT1、T2和B1)。

Clinical studies: Continuation of the cohort study initiated in the second period and inclusion of additional patients with smoldering multiple myeloma for the detection of bone marrow lesions before occurrence of frank bone destructions. High-resolution and functional MRI as well as positron emission tomography for new-detected bone marrow lesions and imaging-guided biopsy of non-osteolytic lesions. Preclinical studies: In vivo analysis of perfusion, diffusion and fine bone structure (SP T1, T2 and B1) using ultra-HF-small animal MRI and micro-CT as well as PET by using standard and BCMA tracers (SP B13) employing a rat and mouse model.