New Chemistry Aimed at Anaerobic Photorelease of Caged Biocides

有机化学和高分子化学计划支持维克森林大学(WFU)的保罗·B·琼斯教授，他试图发现能够在厌氧或好氧条件下通过光化学产生生物活性分子的化学。目前的光动力疗法(PDT)依赖于单线态氧的产生，因此在缺氧组织中的应用有限。许多肿瘤要么本质上缺氧，要么在广泛的化疗或光动力治疗后变得缺氧。尽管目前提出的化学方法不太可能产生一种治疗上有用的PDT试剂，但该项目应该为这种开发提供基础。在项目结束时，在厌氧条件下光化学产生生物活性分子的新化学和新的、合成上有用的光化学反应将是可用的。有机和高分子化学计划支持保罗·B·琼斯教授的工作，他的工作将检查笼状醛的光反应性。琼斯教授的外展活动之一是担任美国学生联合会WFU分会的教师顾问。该组织每年举办一次小型区域化学会议，为西弗尼亚大学的化学学生提供辅导，并以针对小学生的有组织的化学研讨会的形式向当地学校进行推广。

The Organic and Macromolecular Chemistry Program supports Professor Paul B. Jones at Wake Forest University (WFU) who seeks to discover chemistry capable of photochemically generating bioactive molecules under either anaerobic or aerobic conditions. Current photodynamic therapy (PDT) relies on the generation of singlet oxygen and, therefore, is of limited use in hypoxic tissues. Many tumors are either intrinsically hypoxic or become so after extensive chemo- or photodynamic therapy. Though the chemistry presented is not likely to produce a therapeutically useful PDT agent, the project should provide a foundation for such a development. At the conclusion of the project, new chemistry to photochemically generate bioactive molecules under anaerobic conditions and new, synthetically useful, photochemical reactions will be available.The Organic and Macromolecular Chemistry Program supports Professor Paul B. Jones whose work will examine the photoreactivity of caged aldehydes. One of Professor Jones' outreach activities involves being the faculty advisor for the WFU chapter of the ACS-Student Affiliates. This group sponsors an annual regional ACS Meeting in Miniature, provides tutors to WFU chemistry students, and performs outreach to local schools in the form of organized chemistry workshops aimed at elementary school-aged children.