Catalytic Addition of Nucleophiles to Unactivated Olefins

本项目致力于Pd(II)-、Pt(II)-和Au(I)-催化的C-、N-和o -亲核试剂加入非活化烯烃的过程的发展。探讨了pt催化吲哚烷基化反应的范围，并提出了一种有效的烯基吲哚不对称环化反应方案。pt催化的烯基胺的氢胺化反应和烯基氨基甲酸酯的氢胺化反应方法也将被探讨。其他有待研究的反应包括烯的分子内氢化胺化，未活化烯烃的分子间氢化胺化，烯基吲哚的pd催化环化/碳烷氧基化，以及羟基烯烃的pt催化氢化烷氧基化。杜克大学与北卡罗来纳中央大学（NCCU）的暑期交流项目将把北卡罗来纳中央大学的本科生研究人员带到杜克大学。有了这个更新奖，有机和大分子化学项目支持杜克大学化学系Ross A. Widenhoefer博士的研究。Widenhoefer博士正在探索新的合成方法，将简单的有机分子转化为含有新的碳-碳、碳-氮和碳-氧键的更复杂的分子。通过利用含有金属原子的化合物的新化学，特别是钯、铂和金，Widenhoefer博士正在开发简单的工具，用于构建复杂的自然发生和生物活性分子，在制造、精细化学生产、药物发现和合成领域具有潜在的应用。除了杜克大学的学生外，该研究项目还通过暑期研究交流项目吸引了来自北卡罗来纳中央大学的本科生。

This project addresses the development of Pd(II)-, Pt(II)-, and Au(I)-catalyzed processes for the addition of C-, N-, and O-nucleophiles to unactivated olefins. The scope of the Pt-catalyzed alkylation of indoles will be explored, and an effective protocol for the asymmetric cyclization of allenyl indoles will be developed. The Pt-catalyzed hydroamination of alkenyl amines and methodologies for the hydroamination of alkenyl carbamates will also be explored. Additional reactions slated for examination include intramolecular hydroamination of allenes, intermolecular hydroamination of unactivated olefins, Pd-catalyzed cyclization/carboalkoxylation of alkenyl indoles, and Pt-catalyzed hydroalkoxylation of hydroxy olefins. A summer exchange program with North Carolina Central University (NCCU) will bring undergraduate researchers from NCCU to Duke University.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Ross A. Widenhoefer, of the Department of Chemistry at Duke University. Dr. Widenhoefer is exploring new synthetic methods for the conversion of simple organic molecules into more complex molecules containing new carbon-carbon, carbon-nitrogen, and carbon-oxygen bonds. By exploiting the novel chemistry of compounds containing metal atoms, in particular palladium, platinum, and gold, Dr. Widenhoefer is developing simple tools for the construction of complex naturally-occurring and biologically active molecules, with potential applications in the areas of manufacturing, fine chemical production, and pharmaceutical discovery and synthesis. In addition to Duke University students, this research program engages undergraduate students from North Carolina Central University through a summer research exchange program.