New Approaches to Catalyst Screening and Development

该项目将进一步开发创新的筛选方法，以促进组合催化研究，并通过这样做，探索综合有趣的转化。将研究在上一个资助期开发的原位酶促筛选方法的范围。此外，还将研究荧光平板阅读器，以提高筛选方法的吞吐量。这些方法将被用来研究四种不同的反应类型：过渡金属催化的烯丙基取代、乙烯/丙烯基醚的水解性拆分、扩展的环氧化物水解性动力学拆分和不对称烯烃二羟基化。通过这一奖项，有机和高分子化学项目支持了内布拉斯加州大学林肯分校化学系的大卫·B·伯科维茨教授的研究。伯科维茨教授的研究工作围绕着开发高效的组合文库筛选方法，使用酶作为敏感传感器。这种方法可以快速检测大量化合物对有机反应的催化活性。他的研究可能导致发现新的有效催化剂，用于有用的合成转化。

This project will further develop innovative screening methodology to facilitate combinatorial catalysis research, and in so doing, to explore synthetically interesting transformations. The scope of the in situ enzymatic screening methods developed in the last funding period will be studied. In addition, a fluorescence plate reader will be investigated in order to improve the throughput of the screening methods. The resulting methods will be used to study four different reaction classes: transition metal mediated allylic substitution, hydrolytic vinyl/propenyl ether resolution, expanded epoxide hydrolytic kinetic resolution, and asymmetric alkene dihydroxylation. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor David B. Berkowitz of the Department of Chemistry at University of Nebraska-Lincoln. Professor Berkowitz's research efforts revolve around the development of efficient screening methods for combinatorial libraries using enzymes as the sensitive sensors. Such methods allow a large number of compounds to be examined quickly for their catalytic activities for organic reactions. His studies could lead to the discovery of new and efficient catalysts for useful synthetic transformations.