Nicotinic acetylcholine receptors as targets in inflammatory and neurodegenerative processes

预期从这项研究中产生的国家/社区利益具有经济和社会性质。该项目中采用的识别炎症途径和调节的新方法有可能提供在基于新肽/蛋白质的药物设计中至关重要的信息。随着以蛋白质为基础的重磅炸弹药物的年销售额超过100亿美元，这项提议有可能为澳大利亚带来非常显着的经济利益。此外，治疗炎症性疾病的新型治疗药物将减少受影响的人数，从而减少与炎症性疾病相关的身体和情感压力，从而为澳大利亚带来社会效益。

The national/community benefits that are expected to arise from this research are economic and social in nature. The novel approach employed in this project to identify inflammatory pathways and regulation has the potential to provide information that is critical in the design of novel peptide/protein based drugs. With blockbuster protein-based drugs having sales in excess of $10 billion per annum this proposal has the potential for very significant economic benefits for Australia. Furthermore, novel therapeutic agents for inflammatory diseases would have social benefits for Australia by decreasing the number of individuals affected and thereby reducing the physical and emotional stress associated with inflammatory diseases.