Elucidating the chemical and biophysical basis for the bioactivity of cyclotides: ultra-stable proteins from plants

阐明环肽生物活性的化学和生物物理基础：来自植物的超稳定蛋白质

• 批准号: DP0880105
• 负责人: Prof Norelle Daly
• 金额: $ 21.15万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-05-12 至 2011-05-11
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0880105
• 关键词: Elucidating; chemical; biophysical; basis; bioactivity

The national/community benefits that are expected to arise from this research are economic and social in nature. In particular, this project has the potential to increase the national capacity for the development of peptides (mini-proteins) as anti-cancer drugs. With blockbuster protein-based drugs having sales in excess of $10 billion per annum this proposal has the potential for very significant economic benefits for Australia. As well as these economic benefits a novel therapeutic agent for cancer would have enormous social benefits for Australia by decreasing the number of individuals affected and thereby reducing the subsequent emotional and physical distress associated with cancer.

预期从这项研究中产生的国家/社区利益具有经济和社会性质。特别是，该项目有可能提高国家开发作为抗癌药物的多肽(微型蛋白质)的能力。随着以蛋白质为基础的重磅炸弹药物的年销售额超过100亿美元，这项提议有可能为澳大利亚带来非常显着的经济利益。除了这些经济利益外，一种新的癌症治疗剂将通过减少受影响的人数，从而减少与癌症相关的随后的情感和身体痛苦，为澳大利亚带来巨大的社会效益。