Humoral immune reconstitution after allogeneic stem cell transplantation

移植物抗宿主病（GVHD）是异基因造血干细胞移植（SCT）后的主要并发症。患有GVHD的患者遭受长期免疫缺陷，这通常归因于所需的免疫抑制治疗。使用适当的小鼠模型，我们现在的目标是检查GVHD本身是否有助于延迟免疫重建。为此，我们研究了B细胞区室，因为适应性免疫系统的所有组分（T细胞、B细胞和抗原呈递细胞）的协调相互作用是其定量和功能恢复所必需的。因此，检查体液免疫的重建允许在无药物移植模型中评价整个过继免疫系统。该项目的最终目标是确定导致GVHD中免疫缺陷的关键细胞和分子机制，并开发促进移植后耐受和免疫的新策略。

Graft-versus-host disease (GVHD) is a major complication after allogeneic stem cell transplantation (SCT). Patients with GVHD suffer from prolonged immunodeficiency, which is usually attributed to the required immunosuppressive therapy. Using appropriate mouse models, we now aim to examine whether GVHD itself contributes to the delayed immune reconstitution. For this purpose, we examine the B cell compartment, as a coordinated interaction of all components of the adaptive immune system (T cells, B cells and antigenpresenting cells) is required for its quantitative and functional recovery. Thus, examining the reconstitution of humoral immunity permits the evaluation of the entire adoptive immune system in drug-free transplantation models. The final goal of this project is the identification of crucial cellular and molecular mechanisms causing immunodeficiency in GVHD and the development of new strategies fostering tolerance and immunity after transplantation.