Polyboranes: New Syntheses and Reactions

宾夕法尼亚大学化学系Larry G. Sneddon教授，在无机、生物无机和有机金属化学项目的支持下开发聚硼烷化合物。这些化合物的应用范围从抗癌剂到高温聚合物，从核废料的萃取剂到陶瓷前体。由于无法有效地合成或修饰聚硼烷，这些和其他潜在用途的开发受到严重阻碍。该项目通过开发新的高产方法来系统合成重要的聚硼烷化合物、聚合物和材料来解决这些问题。一个项目利用离子液体独特的活化特性来开发新型聚硼烷转化。第二个项目进行了微波辅助离子液体/聚硼烷反应的首次研究。第三个重点是发现新型金属催化方法，从而控制合成修饰和/或聚合。总的来说，这项研究既强调新反应的发现，也强调其基本机制的阐明。该项目的成果将对有机金属化学、催化、药物化学、材料科学和替代能源研究等相关领域产生重大影响。除了科学成果，这项研究还将为本科生、研究生和博士后提供培训。

Professor Larry G. Sneddon, Department of Chemistry, University of Pennsylvania, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program for the development of polyborane compounds. These compounds are involved in applications ranging from cancer agents to high temperature polymers, from extractants for nuclear wastes to ceramic precursors. The exploitation of these and other potential uses has been seriously hampered by the inability to efficiently synthesize or modify the polyboranes. This project addresses these problems by developing new high-yield methods for the systematic syntheses of important polyborane compounds, polymers, and materials. One project uses the unique activating properties of ionic liquids to develop new types of polyborane transformations. A second project undertakes the first investigations of microwave assisted ionic liquid/polyborane reactions. The third focuses on the discovery of new types of metal-catalyzed methods that result in controlled synthetic modifications and/or polymerizations. Overall, the research emphasizes both the discovery of new reactions and the elucidation of their fundamental mechanisms. The results of this project will strongly impact the related fields of organometallic chemistry, catalysis, medicinal chemistry, materials science, and alternative energy research. In addition to the scientific results, this research will provide training to a diverse group of undergraduate, graduate, and postdoctoral students.