Interactions Between MADS-Domain Floral Repressors in the Photoperiod Pathway

唐娜·E Fernandez提案号IOS-0718598标题：光周期途径中MADS域成花抑制因子之间的相互作用植物开花的时间既取决于外部因素，如光照和温度，也取决于内部因素，如植物的年龄和条件。 有关这些因子的信息被输入到一个复杂的正、负作用分子调节器网络中，该网络控制着从叶子形成到花形成的转换。 MADS结构域蛋白AGAMOUS-LIKE 15、AGAMOUS-LIKE 18和短营养期（SVP）通过拟南芥的遗传分析已被鉴定为该网络中的负作用调节因子。 将进行遗传和分子研究，以确定这些因素如何单独和集体地对调控网络做出贡献。 这项工作将深入了解控制开花的调节复合物的性质，它们的作用机制以及它们之间的相互作用。 这些见解将增加对控制发育过程的分子基础的理解，在许多领域具有潜在的影响，从生殖生物学到疾病的发展和作物产量。该项目将为几名本科生和研究生级别的青年科学家提供培训机会。

Donna E. FernandezProposal No. IOS-0718598Title: Interactions between MADS-domain floral repressors in the photoperiod pathway.The time at which a plant flowers depends both on external factors, such as light and temperature, and internal factors, such as the age and condition of the plant. Information about these factors is fed into a complex network of positively- and negatively-acting molecular regulators, which control the switch from formation of leaves to formation of flowers. The MADS-domain proteins AGAMOUS-LIKE15, AGAMOUS-LIKE18, and SHORT VEGETATIVE PHASE (SVP) have been identified as negatively-acting regulators in this network through genetic analyses in Arabidopsis. Genetic and molecular studies will be performed to define how these factors contribute, both individually and collectively, to the regulatory network. This work will give insight into the nature of regulatory complexes that control flowering, their mechanism of action, and interactions between them. These insights will add to the understanding of the molecular basis for control of developmental processes, with potential implications in many areas ranging from reproductive biology to disease development and crop yield. The project will provide training opportunities for several young scientists at the undergraduate and graduate level.