Identifying the pathways employed by growth hormone to regulate the proliferation of adult neural stem cells

由于干细胞支撑着大脑的维持和再生，并且已知随着年龄的增长，干细胞的数量和能力会下降；确切地了解这些细胞是如何被调节的，对整个国家都有好处。此外，鉴于生长激素在整个身体中的调节作用，从这个项目中获得的见解应该会导致在神经系统内外发现新的治疗靶点，最终导致预防和恢复策略，以保持良好的健康。最后，该提案具有重大的国家利益，因为它无疑将推进我们在干细胞生物学方面的知识基础，有助于保持澳大利亚在干细胞研究方面的全球领先地位。

As stem cells underpin the maintenance and regeneration of the brain and are known to decline in number and competence with age; understanding exactly how these cells are regulated is of broad national benefit. Furthermore, given the regulatory role of growth hormone throughout the body, insights gained from this project should lead to the discovery of novel therapeutic targets both within and outside the nervous system, ultimately leading to preventative and restorative strategies for maintaining good health. Finally, this Proposal is of significant national benefit as it will undoubtedly advance our knowledge base in stem cell biology, helping to maintain Australia as a global leader in stem cell research.