MRI: Acquisition of an advanced micro-Computed Tomography imaging facility

CBET-0723027 Cardoso 该提案描述了纽约城市学院（CCNY）的多用户高级成像设施。它包括一个微焦点X射线计算机断层扫描（micro-CT）扫描系统，一个专用的图像采集服务器和四个工作站，用于重建，处理和分析三维数据。成像设施将为纽约市立大学格罗夫工程学院（GSOE）五个工程系中的四个系提供服务，即生物医学工程、机械工程、化学工程和电气工程系，以及纽约市主要医学研究机构的研究伙伴。本提案中要求的微型CT扫描仪和采集系统将设在生物医学工程系的生物力学实验室内。该空间位于纽约市立大学格罗夫工程学院内，因此为所有用户提供了方便的访问。高分辨率微型计算机断层扫描技术是一种新的技术，它彻底改变了材料和组织的无损评估。它提供了一种独特的手段，用于可视化由不同密度的物质组成的复杂结构。特别是，它允许分析高密度组织（骨、钙化动脉、肿瘤等）和填充有高密度造影剂的结构。它还可以产生详细的3-D图像的软组织，脂质和空气的血管内，由于其显着的高灵敏度。显微CT避免了与组织的经典组织学处理相关的几个缺点，例如浸润、脱水和连续切片。虚拟无损组织学是快速获得的一堆连续的图像（横截面），每个图像的厚度为几微米。此外，几个组织形态特征的分析是自动的，减少了测量误差，并允许构建复杂的数值模型。

CBET-0723027 Cardoso This proposal describes a multi-user advanced imaging facility at The City College of New York (CCNY). It comprises a microfocus X-Ray Computed Tomography (micro-CT) scanning system, a dedicated server for images acquisition and four workstations for reconstruction, treatment and analysis of 3-D data. The imaging facility will provide service to four of the five engineering departments in the Grove School of Engineering (GSOE) at CCNY, Biomedical Engineering (BME), Mechanical Engineering (ME), Chemical Engineering (ChE) and Electrical Engineering (EE) and research partners at major medical research institutions in New York City. The micro-CT scanner and acquisition system requested in this proposal will be housed within the Biomechanics Laboratory in the Department of Biomedical Engineering. This space is located within the Grove School of Engineering at CCNY, thus providing convenient access to all the users. High resolution micro-Computed Tomography is a recent technology that has revolutionized the nondestructive assessment of materials and tissues. It provides a unique means for visualization of complex structures composed by substances with different densities. In particular, it permits the analysis of high-density tissues (bone, calcified arteries, neoplasias, etc) and structures filled with high-density contrast agents. It also produces detailed 3-D images of soft tissue, lipid, and air within blood vessels due to its remarkable high sensitivity. Several disadvantages associated with classical histological processing of tissue, such as infiltration, dehydration and serial sectioning is avoided with micro-CT. Virtual nondestructive histology is rapidly obtained as a stack of consecutive images (cross sections) with each image a few microns in thickness. Moreover, the analysis of several histomorphometric features is automatic, reducing measurement errors, and permitting construction of complex numerical models.