CAREER: Synthetic methodology for the preparation of polycyclic nitrogen or oxygen containing heterocycles

有了这一职业奖，有机和高分子化学项目将支持佛蒙特州大学化学系马蒂亚斯·布鲁尔教授的研究。该项目将开发从简单的起始原料合成含氮或含氧有机化合物的新方法。这些方法基于肼与硫离子的反应，将为在温和和环境友好的条件下获得活性中间体提供新的途径。这些活性中间体将被研究其参与史无前例的S型重排、亲电芳香族取代和环加成反应的能力，并将被评估在各种合成转化中的反应性。这项研究将为生物医学研究人员提供新的工具来制备生物活性化合物，这些化合物通常很难用目前的方法合成。布鲁尔教授还将启动教育项目，重点是开发环境友好的绿色化学方法，并将其整合到本科课程中。绿色化学实验将在高水平的有机实验室中开展，供低水平的本科实验室使用。PI还将监督本科生与当地水族馆/科学中心之间的合作，以开发旨在向普通受众介绍环境友好型绿色化学的外展教育材料。

With this CAREER Award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Matthias Brewer of the Chemistry Department at the University of Vermont. This project will develop new methods for the synthesis of nitrogen or oxygen containing organic compounds from simple starting materials. These methods, based on the reaction of hydrazones with sulfonium ions, will provide new ways to access reactive intermediates under mild and environmentally benign conditions. These reactive intermediates will be studied for their ability to participate in unprecedented sigmatropic rearrangements, electrophilic aromatic substitutions, and cycloadditions, and will also be evaluated for reactivity in a variety of synthetic transformations. This research will provide biomedical researchers with new tools to prepare biologically active compounds that are often difficult to synthesize by current methods.Professor Brewer will also initiate educational projects focused on the development of environmentally beneficial green chemical methods and their integration into the undergraduate curriculum. Green chemistry experiments will be developed in senior-level organic laboratories for use in the lower-level undergraduate laboratories. The PI will also oversee a partnership between undergraduate students and a local aquarium/science center to develop outreach educational materials designed to introduce a general audience to environmentally benign green chemistry.