CAREER: Synthesis of Structural and Functional Models for Oxalate Degrading Manganese Enzymes

由无机、生物无机和有机金属化学项目颁发的CAREER奖支持奥克兰大学Ferman Chavez教授开发草酸降解锰酶草酸氧化酶和草酸脱羧酶活性位点的小分子模型的工作。我们将详细研究这些模型对草酸盐的反应性。作为提议的研究的结果，他希望能够帮助阐明这些酶的催化机制，并提供具有增强氧化活性的小分子。拟议的教育部分将包括启动一项高中外展计划。与查韦斯教授的研究相关的实验和演示将被开发出来，作为高中学生课程的一部分来教授基本的化学概念。这些活动将在密歇根东南部地区的高中教室中进行测试。查韦斯教授将以高中化学教师为对象，举办以新发明的实验和示范为主题的研讨会。将发布包含这些信息的实验室工作手册和网站。

This CAREER award by the Inorganic, Bioinorganic and Organometallic Chemistry Program supports work by Professor Ferman Chavez at Oakland University to develop small molecule models for the active sites of oxalate degrading manganese enzymes oxalate oxidase and oxalate decarboxylase. The reactivity of these models towards oxalate will be studied in detail. As an outcome of the proposed investigations, he expects to help clarify mechanisms involved in catalysis for these enzymes as well as provide small molecules with enhanced oxidative activity. The proposed educational component will involve the initiation of a high school outreach program. Experiments and demonstrations related to Professor Chavez's research will be developed to teach basic chemistry concepts to high school students as part of their curriculum. These activities will then be tested in high school classrooms settings in the southeastern Michigan area. Professor Chavez will conduct workshops aimed at high school chemistry teachers featuring newly created experiments and demonstrations. A laboratory workbook and website containing this information will be published.