The Texas Two-step Approach to Priviledged Chirons

本项目主要研究非功能化烯烃的不对称加氢反应。有两个具体目标。一是利用大量非官能化烯烃的不对称加氢制备手性无环分子中的广泛片段；二是优化和改进先前开发的光活性碳恶唑啉催化剂，以促进更多种类的大量非官能化烯烃的对映选择性加氢。这些研究将应用于形成与手性无环分子中一些最基本的构建块相对应的双功能化chirons的所有立体化学排列。通过这个奖项，有机和大分子化学项目支持了德克萨斯农工大学化学系凯文·伯吉斯博士的研究。伯吉斯教授将把他的工作重点放在非官能化烯烃的不对称加氢方法的发展上。一个大范围的真正有用的手性积木将准备。这项工作有可能对制药行业产生更广泛的影响，该项目是培养本科生、研究生和博士后的绝佳场所。

The project focuses on the asymmetric hydrogenation of unfunctionalized alkenes. There are two specific aims. One is to use asymmetric hydrogenation of largely unfunctionalized alkenes to prepare widespread fragments in chiral, acyclic molecules and the other is to optimize and refine the optically active carbene oxazoline catalyst developed previously to facilitate enantioselective hydrogenation of a more diverse set of largely unfunctionalized alkenes. These studies will be applied to form all stereochemical permutations of difunctionalized chirons that correspond to some of the most fundamental building blocks in chiral, acyclic molecules.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Kevin Burgess in the Department of Chemistry at Texas A&M University. Professor Burgess will focus his work on the development of methodology for the asymmetric hydrogenation of unfunctionalized alkenes. A great range of genuinely useful chiral building blocks will be prepared. The work has the potential for broader impact in the pharmaceutical industry and the project serves as an excellent venue for the training of undergraduates, graduate students, and postdoctoral fellows.