MRI: Acquisition of a Gemini R Ultra X-ray Diffractometer for Structural Biology and Chemistry

获得重大研究仪器计划(MRI)的这一奖项后，来自高露洁大学的Roger Rowlett及其同事Anthony Chianes和G.Richard Geier III将获得一台单晶X射线衍射仪(XRD)，以支持化学和生物化学方面的研究，包括研究酶的机制和结构、有机金属催化、卟啉大环以及检测大肠杆菌中细菌碳酸酐酶的机制。该仪器还将影响高露洁和地区性本科院校的本科生研究、培训和教学。单晶X射线结晶学技术可以准确和精确地确定分子的全部三维结构，包括键的距离和角度，并提供关于分子相对于邻近分子的空间排列的准确信息。这些研究将在许多领域产生影响，从合成化学到具有生物学意义的系统。

With this award from the Major Research Instrumentation program (MRI), Roger Rowlett and colleagues Anthony Chianese and G. Richard Geier III from Colgate University will acquire a single-crystal X-ray diffractometer (XRD) to support research in chemistry and biochemistry including the study of enzyme mechanisms and structure, organometallic catalysis, porphyrinic macrocycles as well as examination of the mechanism of bacterial carbonic anhydrase in E. coli. The instrumentation will also impact undergraduate research, training, and teaching at Colgate and regional undergraduate institutions. The technique of single-crystal X-ray crystallography allows accurate and precise determination of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of molecules relative to the neighboring molecules. These studies will have an impact in a number of areas ranging from synthetic chemistry to systems of biological interest.