MRI: Acquisition of an LCMS for the Chemistry Department at the University of Vermont

凭借重大研究仪器计划(MRI)的这一奖项，德怀特·马修斯和密歇根州立大学的同事朱塞佩·佩特鲁奇、马蒂亚斯·布鲁尔、马丁·凯斯、威廉·盖格、托马斯·休斯以及凯文·基特里奇(锡耶纳学院)和琳达·勒克(纽约州立大学普拉茨堡分校)将获得一种低流量液体色谱仪串联质谱仪(LC-MS/MS)系统，该系统将加强UV、锡耶纳学院和纽约州立大学普拉茨堡分校之间的合作。这些合作努力将加强该区域的研究和教育基础设施。该仪器将用于七个具体的研究活动：(1)生物医学应用的含氮或含氧的复杂多环化合物的合成，(2)肽的自结合，(3)未活化的烯烃的C-C偶联反应，(4)使用大环前驱体合成短的单壁纳米管片段，(5)冠醚修饰的单分子层保护簇合物的连接机制，(6)雌激素干扰化合物的生物传感器的开发，以及(7)挥发性和半挥发性有机化合物在空气颗粒物上与环境相关的多相反应。质谱学(MS)是一种用于探测密切结构细节并获得大量有机、生物有机和有机金属分子的分子组成的技术。这项研究也有望对环境产生积极影响。质谱法是发展最快、应用最广泛的分析仪器技术之一。正因为如此，研究生和本科生接触到这项技术是很重要的。大致来说，串联质谱仪可以被认为是两个串联的质谱计，由一个腔室连接，该腔室可以将化学物质分解成碎片，以便于分析。

With this award from the Major Research Instrumentation program (MRI), Dwight Matthews and UVM colleagues Giuseppe Petrucci, Matthias Brewer, Martin Case, William Geiger, Thomas Hughes as well as Kevin Kittredge (Siena College) and Linda Luck (SUNY, Plattsburgh) will acquire a low-flow liquid-chromatograph tandem mass spectrometer (LC-MS/MS) system that will increase collaboration amongst UV, Siena College and the State University of New York at Plattsburgh. These collaborative efforts will enhance the research and educational infrastructure of the region. The instrumentation will be used in seven specific research activities: (1) synthesis of complex N- or O-containing polycyclic compounds for biomedical application, (2) self-association of peptides, (3) C-C coupling reactions of unactivated olefins, employing an organorhenium electron-transfer mediator, (4) use of macrocyclic precursors to synthesize short single-wall nanotubes segments, (5) linking mechanisms of crown ether modified monolayer-protected clusters, (6) development of biosensors for estrogen disrupting chemicals, and (7) environmentally relevant heterogeneous reactions of volatile and semi-volatile organic compounds on airborne particles.Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. This research is also expected to have a positive effect on the environment. MS is one of the fastest growing and most widely used analytical instrumentation techniques. Because of this, it is important for graduate and undergraduate students to be exposed to the technique. To a first approximation a tandem mass spectrometer can be thought of as two mass spectrometers in series connected by a chamber that can break a chemical species into pieces to facilitate analysis.