MRI: Acquisition of a 500 MHz NMR Spectrometer for Chemistry at the University of Vermont

佛蒙特州州立大学农业学院的德怀特·马修斯教授及其同事朱塞佩·佩特鲁奇和马蒂亚斯·布鲁尔获得了来自主要研究仪器(MRI)计划的这一奖项，他们将获得一台具有固体和溶液能力的500 MHz核磁共振波谱仪。该奖项将加强各个层面的研究培训和教育，特别是在以下领域：(A)用于催化和生物医学应用的纳米多孔材料的合成；(B)具有磷基分子结构的聚合物；(C)邻位二硫键的顺式/反式异构化对烟碱型乙酰胆碱受体的影响；(D)通过2-氮杂-钴-偶极环加成方法合成的N-杂环体系的制备；以及(E)含氮或含氧杂环的制备。核磁共振波谱是化学家可用于阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将是佛蒙特大学和邻近学院如纽约州立大学普拉茨堡分校、圣迈克尔学院、米德尔伯里学院和奥尔巴尼药学与健康科学学院教学和研究不可或缺的一部分。

With this award from the Major Research Instrumentation (MRI) Program, Professor Dwight Matthews from University of Vermont & State Agricultural College and colleagues Giuseppe Petrucci and Matthias Brewer will acquire a 500 MHz NMR spectrometer with solids and solution capabilities. The award will enhance research training and education at all levels, especially in areas such as (a) synthesis of nanoporous materials for catalytic and biomedical applications, (b) polymers with phosphorus-based molecular architectures, (c) effect of cis/trans Isomerization of vicinal disulfide bond on the nicotinic acetylcholine receptor, (d) preparation of N-heterocyclic systems synthesized following a 2-aza-Cope-dipolar cycloaddition approach, and (e) preparation of nitrogen or oxygen containing heterocycles.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research at the University of Vermont and neighboring colleges such as SUNY Plattsburg, St Michael's College, Middlebury College and Albany College of Pharmacy and Health Science.