CAREER: Catalytic Aldimine Coupling: A Versatile Carbon-Carbon Bond Forming Reaction

本研究项目旨在开发一种氰化物催化的醛胺偶联反应，针对多种分子结构，包括碳环、杂环、大环、二聚体、配体、低聚体、共轭和非共轭聚合物。将探讨用其他催化剂替代氰化物的可能性，从而与计划发展的环境和分子化学模块和课程的可持续性（绿色化学）重点联系起来。在有机和大分子化学项目颁发的CAREER奖的支持下，德克萨斯农工大学化学系的Stephen a . Miller教授正在探索一套由氰化物催化的独特反应。这种反应化学为许多新的有机产物的产生提供了希望，具有潜在的应用，包括药物，有机染料和均相催化领域。在效率和催化方面，简单的双原子氰化物阴离子是显著的，特别是与高度工程化和昂贵的贵金属催化剂相比。效率和催化的概念也是米勒教授教育活动的组成部分。通过一门关于环境分子观的课程，德克萨斯州的高中教师和学生将接触到环境化学主题，包括绿色化学12原则之一的催化原理、分支和无处不在的现象。环境化学写作课程为学生在科学和可持续发展的跨学科性质方面提供了额外的经验。

This research project addresses the development of a cyanide-catalyzed aldimine coupling reaction, targeting a number of molecular structures, including carbocycles, heterocycles, macrocycles, dimers, ligands, oligomers, and conjugated as well as non-conjugated polymers. The potential replacement of cyanide by alternate catalysts will be explored, providing a link to the sustainability (green chemistry) focus of the environmental and molecular chemistry modules and courses planned for development.With the support of this CAREER award from the Organic and Macromolecular Chemistry Program, Professor Stephen A. Miller, of the Department of Chemistry at Texas A&M University, is exploring a unique set of reactions catalyzed by cyanide. This reaction chemistry offers promise for the generation of many novel organic products, with potential applications including the areas of pharmaceuticals, organic dyes, and homogeneous catalysis. In the context of efficiency and catalysis, the simple, two-atom cyanide anion is remarkable, especially when compared to highly engineered and expensive precious metal catalysts. The concepts of efficiency and catalysis are also integral to the educational activities of Professor Miller. Through a course on a Molecular View of the Environment, high school teachers and students across the state of Texas are exposed to environmental chemistry topics, including the principles, ramifications, and ubiquity of catalysis, one of the 12 Principles of Green Chemistry. A writing course on Environmental Chemistry provides additional experience for students in the interdisciplinary nature of science and sustainability.